Kristy Camille I. Deang ,
Fritzie Dianne . Lagman,
Jen F. Magpayo,
Joshua ith D. Mendoza,
Ma. Patricia Aykamille Danes B. Paguio
This study determined the oral acute toxicity of Sanseviera trifasciata on Albino mice (Mus musculus). Specifically, it determined the toxic risks, organ and body weight effects, tissue damage of vital organs, and hepatotoxicity through toxic risk examination, organ and body weight analysis, histopathology analysis and liver function test. There are lytic necrosis and nephrosis in liver and kidney resulted in histopathology examination. There are significant changes for the serum levels of total bilirubin levels (TBIL), alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) the significance is (P<0.05). The body weight and organ analysis, treated group have an increase in mass, more importantly liver. There is an enlargement of all primary organs on the treated group compared to the control group, which indicates that Strifasciata can caused injury to vital organs, the histopathology analysis collaborated with the results of body weight and organ weight. The leaves extract of S. trifasciata cause a toxicity towards the organs as there was a structural damage to the tested organs of liver, kidney, lungs and spleen of the mice. ALT significantly increases on the treated group. Results showed that ethanol extract of S. trifaciata caused an in vivo toxicity in an animal model, with 50% mortality rate. According to the series of test, it has toxic property to the organs and increase ALT level. This plant cannot be used as a medicinal agent orally, at doses 5000 mg/kg or higher, especially in rural communities where conventional drugs are unaffordable because of their high cost.