Nomar T. Caranto,
Maja Katherine M. Blanco,
Erica Christine M. Baltazar,
Adora Gaye V. Tiglao,
John Paul T. Martinez,
Pancho Carlo P. Tranquilino,
Mariella D. Lopez,
Immanuel B. De Guzman,
School of Medicine - Angeles University Foundation
The ABO blood group was discovered in 1900 by Austrian scientist, Karl Landsteiner At present, the International Society of Blood Transfusion (ISBT) approves 29 human blood group systems, one of which is the ABO blood group system (Hosoi, 2008).
The ABO blood system consists of four antigens (A, B, O and AB). O type red blood cells lack A or B antigens. These antigens are carbohydrates attached to a precursor backbone, may be found on the cellular membrane either as glycosphingolipids or glycoproteins, and are secreted into plasma and body fluids as glycoproteins. H substance is the immediate precursor on which the A and B antigens are added. This H substance is formed by the addition of fructose to the glycolipid or glycoprotein backbone. The subsequent addition of N-acetylgalactosamine creates the A antigen, while the addition of galactose produces the B antigen.
1. (MD) Angeles University Foundation, 2010